Which of the following is a mineralocorticosteroid?

• A. Deca-Durabolin
• B. Aldosterone
• C. Cortisone
• D. Hydrocortisone

Answer: (A)

Mineralocorticoids regulate electrolyte and fluid balance by acting on the kidneys to promote sodium reabsorption and potassium excretion, which helps control blood volume and pressure. The principal mineralocorticoid is aldosterone, produced in the adrenal cortex, and it acts on the distal tubules and collecting ducts to increase sodium reabsorption (and water follows) while promoting potassium excretion. Deca-Durabolin is an anabolic steroid focused on muscle growth, not mineralocorticoid action. Cortisone and hydrocortisone are glucocorticoids involved in metabolism and anti-inflammatory responses, with only minor mineralocorticoid activity compared to aldosterone. Therefore, the mineralocorticoid is aldosterone.